Antibody-dependent cytotoxicity(ADCC)
The immune effector cell’s Fc receptor (also known as FCGR) binds to the Fc region of an antibody, which binds to a target cell selectively, causing antibody-dependent cellular cytotoxicity (ADCC). Non-specific cytotoxic cells including natural killer cells, macrophages, monocytes, and eosinophils can mediate ADCC. The phosphorylation of the FCGR ITAM occurs when FCGR attaches to…