If you are using Modalert for night shift work, it is usually recommended to take it about 1-2 hours before your shift begins. This timing allows the medication to take full effect during your shift, keeping you awake and alert. Because Modalert has a long half-life, taking it too late during your shift may affect your ability to sleep after work. It is important to follow your doctor’s instructions regarding timing and dosage to avoid disrupted sleep patterns and side effects such as insomnia and restlessness.